Pair Name	Berbamine, Aspirin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Gene Regulation	Down-regulation	Phosphorylation	CREB1	hsa1385
	Down-regulation	Phosphorylation	ATF1	hsa466
	Down-regulation	Expression	CIP2A	hsa57650
	Down-regulation	Expression	CCND1	hsa595
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
	Hep 3B2.1-7	Childhood hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0326
In Vivo Model	HepG2 cells (4×10⁶ in 125 μL PBS) were subcutaneously injected into 5-week-old BALB/c nude mice.
Result	These data demonstrate that the regulation of cAMP-PKA-CREB/ATF1 signaling represents a noncanonical function of CPS1. Targeting the PKA-CREB/ATF1 axis may be a strategy to improve the therapeutic effects of aspirin on HCC.